000			04297cam a2200685 i 4500
001			u12826
003			SA-PMU
005			20210418123058.0
008			151026s2016 maua b 001 0 eng c
010			_a 2015042054
040			_aMH/DLC _beng _erda _cHLS _dDLC _dPUL _dYDXCP _dBTCTA _dBDX _dOCLCF _dNYP _dWEA _dCHVBK _dNLM _dNRC _dOCLCQ _dCSJ _dOCLCO
016	7		_a101684921 _2DNLM
020			_a9780674088740 _q(alk. paper)
020			_a0674088743 _q(alk. paper)
035			_a(OCoLC)926061404
042			_apcc
050	0	0	_aRC269.7 _b.L37 2016
060	0	0	_a2016 E-841
060	1	0	_aQZ 202
082	0	0	_a616.99/407 _223
100	1		_aLaplane, Lucie, _d1984- _eauthor.
245	1	0	_aCancer stem cells : _bphilosophy and therapies / _cLucie Laplane.
264		1	_aCambridge, Massachusetts : _bHarvard University Press, _c2016.
300			_ax, 252 pages : _billustrations ; _c25 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
520			_a"An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells--with harmful side-effects for patients--CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells--the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation. To date, researchers have not agreed on the defining feature of CSCs--their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell's relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to cure cancers may well depend upon determining how these definitions apply to different types of cancers."-- _cProvided by publisher.
504			_aIncludes bibliographical references and index.
505	0		_aPart I. Cancer stem cells: a new theory of cancer -- Cancer stem cells' triumph -- The CSC theory -- Part II. The historical emergence of the CSC concept and its driving role in cancers -- Teratocarcinomas and embryonic stem cells (nineteenth-twentieth century) -- Leukemic and hematopoietic stem cells -- Part III. Debates on CSCs and stem cells: what are they? -- Origin, stemness, and stem cells: the meaning of words -- Stem cell identity -- Part IV. The identity of stemness and its consequences for cancer therapies -- If stemness is a categorical or a dispositional property, how can we cure cancers? -- If stemness is a relational or systemic property, how can we cure cancer?
650		0	_aCancer cells.
650		0	_aStem cells.
650		0	_aCancer _xTreatment _xPhilosophy.
650		0	_aOncology.
650	1	2	_aNeoplastic Stem Cells.
650	2	2	_aStem Cells.
650	2	2	_aNeoplasms _xtherapy.
650		7	_aCancer cells. _2fast _0(OCoLC)fst00845563
650		7	_aCancer _xTreatment _xPhilosophy. _2fast _0(OCoLC)fst00845550
650		7	_aOncology. _2fast _0(OCoLC)fst01045739
650		7	_aStem cells. _2fast _0(OCoLC)fst01132975
650		4	_aCancer cells.
650		4	_aCancer _xTreatment _xPhilosophy.
650		4	_aOncology.
650		4	_aStem cells.
938			_aBrodart _bBROD _n114546800
938			_aBaker and Taylor _bBTCP _nBK0017857147
938			_aYBP Library Services _bYANK _n12652671
029	1		_aAU@ _b000056304716
029	1		_aCHBIS _b010557160
029	1		_aCHDSB _b006483869
029	1		_aCHVBK _b357667204
029	1		_aCHVBK _b363680977
029	1		_aGBVCP _b839091311
029	1		_aNLM _b101684921
942			_cBOOK
994			_aZ0 _bSUPMU
948			_hNO HOLDINGS IN SUPMU - 123 OTHER HOLDINGS
596			_a1 2
999			_c1457 _d1457